Amy Schumer Celebrates Weight Loss Journey with Friends in Las Vegas

On October 4, 2025, comedian and actress Amy Schumer shared a striking Instagram post showcasing her impressive weight loss while enjoying a trip to Las Vegas with friends Alex Saks and Jillian Bell. The 44-year-old star posed confidently in a chic Miu Miu button-down mini shirt dress, complemented by elegant black heels, highlighting her slimmer figure that has garnered attention and praise from fans and friends alike.

The comments section exploded with compliments, with skincare expert Georgia Louise encouraging Schumer to show off her legs more, while filmmaker Lee Daniels playfully referred to her as “Skinnnnnnnny mommmmma.” Margaret Joseph from the Real Housewives of New Jersey chimed in with enthusiasm, exclaiming, “Ok legs for days!!🔥🔥❤️.”

Schumer has been candid about her weight loss journey, discussing her experiences with weight loss drugs such as Ozempic and Mounjaro. In a previous interview, she described her “horrible experience” with Ozempic, revealing that it left her bedridden and struggling with severe nausea, a side effect linked to her genetic predisposition. “I tried Ozempic almost three years ago, and I was, like, bedridden. I was like, vomiting — and then you have no energy,” she shared during a January appearance on Howard Stern’s SiriusXM show.

Despite the challenges she faced with Ozempic, Schumer has found success with a new combination of medications: estrogen and progesterone to alleviate her perimenopause symptoms, alongside Mounjaro, a GLP-1 drug commonly prescribed for type 2 diabetes that is also used for weight loss. In her March Instagram post, she expressed her satisfaction with the results: “My symptoms of being in perimenopause have disappeared. My hair is fuller, my skin is better, I have more energy.”

Schumer has emphasized the importance of transparency regarding weight loss and health in the entertainment industry. “Everybody on camera is doing this s—, I just wanted to be real about it,” she stated in an interview with The Hollywood Reporter. Her commitment to authenticity resonates with fans, as she continues to navigate her health journey in the public eye.

As Schumer embraces her new look and improved well-being, her story serves as a reminder of the complexities surrounding weight loss and the importance of being open about personal experiences in the quest for health and happiness.